Comparison of biophysical models with experimental data for three cell lines in response to irradiation with monoenergetic ions - WP3: Radiobiologie, instrumentation et modèles pour une thérapie innovante
Article Dans Une Revue Physics and Imaging in Radiation Oncology Année : 2019

Comparison of biophysical models with experimental data for three cell lines in response to irradiation with monoenergetic ions

Résumé

HighlightsThe accuracy of biophysical modeling is crucial for particle therapy.Comparison of LEM(I-IV), MKM and NanOx models with data for 3 cell lines. χ2 scoring for α(LET) curves. NanOx yields the highest score more often than the other models.AbstractThe relative biological effectiveness (RBE) in particle therapy is currently estimated using biophysical models. We compared experimental measurements to the α curves as function of linear energy transfer computed by the Local Effect Model (LEM I-IV), the Microdosimetric Kinetic Model (MKM) and the NanOx model for HSG, V79 and CHO-K1 cells in response to monoenergetic irradiations. Although the LEM IV and the MKM predictions accurately reproduced the trend observed in the data, NanOx yielded a better agreement than the other models for more irradiation configurations. Itsestimator was indeed the lowest for three over seven considered cases.
Fichier principal
Vignette du fichier
S2405631619300326.pdf (529.37 Ko) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-02543068 , version 1 (21-07-2022)

Licence

Identifiants

Citer

Caterina Monini, Gersende Alphonse, Claire Rodriguez-Lafrasse, Etienne Testa, Michael Beuve. Comparison of biophysical models with experimental data for three cell lines in response to irradiation with monoenergetic ions. Physics and Imaging in Radiation Oncology, 2019, 12, pp.17-21. ⟨10.1016/j.phro.2019.10.004⟩. ⟨hal-02543068⟩
75 Consultations
42 Téléchargements

Altmetric

Partager

More